Cameron G. Roberts

Cysteine reactivity profiling links metabolic rewiring to the dysfunctional human T cell proteome.

In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.

A functional screen for ubiquitin regulation identifies an E3 ligase secreted by Pseudomonas aeruginosa

This study identifies a novel E3 ligase secreted by Pseudomonas aeruginosa that regulates virulence through ubiquitin modification.

Optic nerve innervation promotes Wnt/b-catenin pathway activity and progenitor cell proliferation in the zebrafish optic tectum

The paper investigates how optic nerve innervation affects Wnt/b-catenin pathway activity and progenitor cell proliferation in zebrafish optic tectum, showing that innervation promotes survival and proliferation even in darkness.

Cyclic tetra-adenylate triggers Cap1 membrane pore opening and depolarization during the type III CRISPR immune response

This study reveals how cyclic tetra-adenylate binds to Cap1, inducing conformational changes that open a membrane pore and cause depolarization during the type III CRISPR immune response.

A bacterial TIR-based immune system senses viral capsids to initiate defense

This study identifies how bacterial TIR domains recognize viral capsids to initiate defense by forming complexes that trigger NAD+ depletion.