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This study investigates APP's role in the endomembrane system, showing its impact on FE65 localization, ATF4 levels, and autophagy regulation.

This study shows that sub-anesthetic ketamine reduces dyskinesia and improves motor function in female preclinical models of Parkinson's disease and L-DOPA-induced dyskinesia.

This study shows APOE4 worsens Aβ oligomer-induced synaptotoxicity by promoting autophagic degradation of STIM1 and Gpx4, leading to mitochondrial dysfunction and synaptic loss.

This study uses volumetric ultrasound localization microscopy to identify two reproducible gradients of cerebrovascular structure and flow in mice, defining axes of vascular density/flow complexity and flow speed/acceleration.

The paper investigates how different decision-making strategies in mice affect cortical activity and identifies frontal cortex involvement in engaged strategies.

This study shows that prolonged low-dose inhalation of paraquat in mice causes male-specific dopaminergic neuron loss and motor deficits, linking it to Parkinson's disease.

This study shows OPCs do not die during development, adulthood, remyelination, inflammation, or aging, indicating homeostasis does not rely on programmed cell death.

The paper shows that a balanced excitatory/inhibitory neuronal network can generate gliders that interact and compute, with high capacity near balance and low capacity with strong inhibition.

This study examines caudate nucleus aging across species and diseases, identifying shared and disorder-specific age-related changes in cell types and regulatory features.

This study shows that dogs and humans have similar neural representations of human bodily emotions, with happiness and anger encoded asymmetrically in distinct brain regions.

This paper introduces CircuitGNN, a graph neural network that infers neural connectivity from population activity, showing high accuracy and robustness across different circuit sizes and recording conditions.

The paper develops a pipeline to estimate structural and functional connectomes from lesion masks to predict post-stroke recovery outcomes, showing better performance than traditional methods.

This study shows that intrinsic thalamic fluctuations before stimulus onset modulate conscious perception by compensating for stimulus strength and enabling efficient information processing.

ConfUSIus provides an open-source toolkit for analyzing functional ultrasound imaging data, unifying processing steps and improving accessibility and reproducibility.

The paper predicts alcohol-use trajectories in adolescents and young adults by analyzing social context, social affective benefit, and fronto-striatal neural involvement over one year.

This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.

This study examines how trait mindfulness affects cortisol changes and mood reactivity after a negative mood induction, finding that mindfulness moderates these relationships.

The paper examines how cortical bursts influence phase synchrony development in preterm infants and links persistent phase-based connectivity to poorer neurocognitive outcomes.

This study investigates how a genetic polymorphism in ADRA2B affects responses to vagus nerve stimulation, finding it influences pupillary responses and cortical activity alignment with noradrenergic projections.

This study shows imipramine binds to amyloid-β, reduces Aβ accumulation, and improves survival in Alzheimer's patients.