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This study uses micro-CT radiomics to classify thyroid tumors and identify biomarkers, showing potential for improving diagnostic accuracy.

This study shows that loss of HNF1B contributes to IPMN initiation and identifies its role as a tumor suppressor in pancreatic ductal cells.

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.

HistoTME-v2 predicts cell type-specific transcriptomic signatures and spatial distributions from H&E images, outperforming baselines across 25 tumor types and multiple validation datasets.

The paper investigates LPS expression in breast cancer cells and finds no evidence of LPS in cancer cells, but detects it in ducts and immune cells.

This study shows WT1 promotes fibroblast survival and ECM production in IPF by impairing apoptotic clearance.

This study compares histological features of carotid plaques between Chinese and U.S. patients, finding differences in lipid pools, intraplaque hemorrhage, and fibrous cap disruptions.

This study identifies endosomal pathway dysfunction in DMD muscle cells and shows that Rab5 upregulation contributes to endosomal defects, which can be mitigated by Rab5 knock-down or dystrophin restoration.

This study examines survival times and prognostic factors in dogs with haemangiosarcoma in UK first-opinion practice, finding short median survival times and identifying key predictors of outcome.

This study classifies porcine atherosclerotic plaques into four types that correspond to human coronary atherosclerosis types, using morphological and cellular features from FH pigs fed a high-fat diet.

This study shows that probiotic treatment alleviates colitis in naked mole rats caused by Citrobacter braakii, offering a new model for studying inflammatory bowel disease.

This study uses lipidomics to identify sex differences in lipid metabolism in fibro-calcific aortic valve disease.

Laser-microdissected islets of 3 multiple-autoantibody-positive stage 1 type 1 diabetes donors versus matched controls show 202 altered proteins: immune and glycolytic up, translation and ER-stress proteins down.

This study uses a zebrafish model of Bethlem myopathy to show that collagen VI deficiency disrupts CaV1.1 function, leading to increased sarcoplasmic reticulum Ca2+ leak and muscle dysfunction.

This study compares phage therapy outcomes using mixed versus single bacterial isolates from an MRSA case study, finding mixed isolates better predict lung infection outcomes than blood infection outcomes.

This study evaluates the prognostic value of Ki-67, BAX, caspase-3, and VEGF-A in feline intestinal lymphoma, finding associations between biomarker expression and survival outcomes.

The paper identifies a biomarker panel responsive to treatment in cardiac hypertrophy and aging, showing that galectin-3 C-epitope, ANP, PPIA, and albumin levels decrease with therapeutic intervention in rat models and human patients.

This study shows fibronectin-binding integrins drive ER stress in endothelial cells under atherogenic conditions, promoting inflammation through JNK-c-Jun signaling.

The paper develops an integrative imaging pipeline combining micro-CT and scanning electron microscopy with histology to enhance lung tissue analysis by adding 3D context and ultrastructural details.