Miguel Parreira Soares

This study shows that age-related decline in adipose tissue lipolysis reduces disease tolerance to SARS-CoV-2, increasing mortality in older mice and correlating with human COVID-19 severity.

This study identifies two anti-ferroptosis pathways in iron-recycling macrophages that prevent cell death and maintain iron homeostasis, revealing a key role for ferroptosis in iron deficiency anemia.

This study shows that BVRA's catalytic activity is essential for malaria resistance and identifies a bilirubin concentration threshold needed for protection.

The paper identifies unconjugated bilirubin as a protective metabolite against malaria by inhibiting parasite proliferation and hemozoin formation.

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.

This study shows that monocyte-derived macrophages regulate energy homeostasis by responding to iron metabolism dysregulation in parenchyma cells.