Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PathologybioRxivPreprint5 citations
- PathologyScientific ReportsPeer-reviewed
Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea
Léna Meneux, Nadège Feret, Sarah Pernot…·Frédéric Michon
This study shows that OPA1 mutation causes corneal innervation issues, including reduced sensitivity and impaired regeneration, despite normal epithelial function.
5 citations - PathologyJournal of Invertebrate PathologyPeer-reviewed
A honey bee-associated virus remains infectious and quantifiable in postmortem hosts
Alexandria N. Payne, Vincent Prayugo, Adam G. Dolezal
This study shows that IAPV remains infectious and quantifiable in postmortem honey bees for at least 48 hours.
6 citations - PathologyJournal of Cachexia Sarcopenia and MusclePeer-reviewed
Different outcomes of endurance and resistance exercise in skeletal muscles of Oculopharyngeal muscular dystrophy.
Alexis Boulinguiez, Jamila Dhiab, Bárbara Crisol…·Capucine Trollet
This study compares the effects of endurance and resistance exercise on OPMD skeletal muscle in mice, finding that resistance exercise reduces PABPN1 aggregates and reverses muscle atrophy, while endurance exercise increases aggregates and collagen deposition.
3 citations - PathologyPlant PathologyPeer-reviewed
Two new qPCR assays for detecting and quantifying the Aspergillus flavus and Aspergillus parasiticus clades in maize kernels
Alexandre Leharanger, Delphine Paumier, Béatrice Orlando…·Romain Valade
The paper develops two qPCR assays to detect and quantify Aspergillus flavus and A. parasiticus clades in maize kernels, showing strong correlations between DNA and aflatoxin levels.
5 citations - PathologybioRxivPreprint
Ethanol exposure model in zebrafish causes phenotypic, behavioral and gene expression changes that mimic Fetal Alcohol Spectrum Disorders in human birth cohorts
Elanur Yılmaz, Nastasia N. Nelson, Giuseppe Tosto…·Çağhan Kızıl
DOI 10.1101/2024.08.05.606708 - PathologyF1000ResearchPeer-reviewed
Treatment options for Chagas Disease: a systematic review and meta-analysis applied to the preclinical studies using animal models
Laura Yesenia Machaca-Luque, Mayron Antonio Candia-Puma, Brychs Milagros Roque-Pumahuanca…·Miguel Angel Chávez-Fumagalli
This study reviews and analyzes preclinical treatments for Chagas disease using animal models, finding promising candidates but limited clinical success.
DOI 10.12688/f1000research.150723.2 - PathologybioRxivPreprint
Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins
Ting Zhou, Huan Min Yang, Carmel Rebecca Assa…·Bo Liu
This study shows that myeloid-specific thrombospondin-1 deficiency increases aortic rupture risk by suppressing extracellular matrix proteins and inflammation in aneurysms.
- PathologyRespiratory ResearchPeer-reviewed
Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats
Qian Jiang, Qifeng Yang, Chenting Zhang…·Yuqin Chen
This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.
7 citations - PathologybioRxivPreprint
A systematic review quantifying host feeding patterns of Culicoides species responsible for pathogen transmission
Emma Louise Fairbanks, Michael J. Tildesley, Janet M. Daly
This study quantifies host feeding patterns of Culicoides species, finding some exhibit fixed preferences while others are opportunistic, with geographic variations influencing behavior.
- PathologybioRxivPreprint
The Plasmodiophora brassicae effector PbEGF1 manipulates plant immunity and regulate primary infection
Hui Yang, Yushu Xu, Yushan Zhao…·Junbo Du
This study identifies PbEGF1, an effector from Plasmodiophora brassicae, which manipulates plant immunity and promotes infection by degrading BnNHL13.
DOI 10.1101/2024.07.23.604797 - PathologyPLoS ONEPeer-reviewed
CircRNA_012164/MicroRNA-9-5p axis mediates cardiac fibrosis in diabetic cardiomyopathy
Honglin Wang, Biao Feng, E. Z. R. Wang, Subrata Chakrabarti
This study identifies a circRNA_012164/miR9-5p axis that promotes cardiac fibrosis in diabetic cardiomyopathy through regulation of fibrotic gene expression.
- PathologybioRxivPreprint
The multifaceted process of human coronary atherosclerotic cap destabilisation
Laura E. Bruijn, Natascha Fonseca Neves, Connie M. Janssen‐van Rhijn…·Jan H.N. Lindeman
This study maps the qualitative changes in coronary atherosclerotic cap characteristics during lesion progression and destabilization using a pseudo-timeline approach.
- PathologyPLoS ONEPeer-reviewed
Comparative analyses of adsorbed circulating proteins in the PMMA and PES hemodiafilters in patients on predilution online hemodiafiltration
Md. Shoriful Islam, Shingo Ema, Md. Mahamodun Nabi…·Mitsutoshi Setou
This study compares protein adsorption by PMMA and PES hemodiafilters in OL-HDF, finding PMMA adsorbs more inflammatory proteins like IL-6 and beta-2 microglobulin.
4 citations - PathologyCancer SciencePeer-reviewed
Discovering cancer stem-like cells using Spatial transcriptomic analysis: Nuclear factor I X as a novel therapeutic target for gastric cancer
Akira Ishikawa, Takafumi Fukui, Aya Kido…·Wataru Yasui
This study identifies NFIX as a critical regulator of cancer stemness in gastric cancer using spatial transcriptomic analysis and shows its correlation with poor prognosis.
6 citations - PathologybioRxivPreprint
An epidemiological description of rabies outbreaks in Zambia from 2013 to 2023.
Humphrey Banda, Amos Hamukale, Chitwambi Makungu…·Kachinda Wezi
The paper analyzes rabies outbreaks in Zambia from 2013 to 2023, identifying trends in cases and risk zones through epidemiological methods and spatial analysis.
DOI 10.1101/2024.07.16.603659 - PathologybioRxivPreprint
Endomucin knockout leads to delayed retinal vascular development and reduced ocular pathological neovascularization
Zhengping Hu, Issahy Cano, Anton Lennikov…·Patrìcia A. D'Amore
This study shows that Endomucin deficiency delays retinal vascular development and reduces pathological neovascularization in mouse models.
DOI 10.1101/2024.07.16.603729 - PathologyHistopathologyPeer-reviewed
Development of a Deep Learning model Tailored for HER2 Detection in Breast Cancer to aid pathologists in interpreting HER2-Low cases
Pierre‐Antoine Bannier, Glenn Broeckx, Loïc Herpin…·Sheeba Irshad
This paper develops a deep learning model to detect HER2 status in breast cancer, showing higher concordance with ground truth than pathologists for HER2-low cases.
- PathologybioRxivPreprint
Moderate-term dimethyl fumarate treatment reduces pathology of dystrophic skeletal and cardiac muscle in a mouse model
Stephanie Kourakis, Cara A. Timpani, Ryan M. Bagaric…·Emma Rybalka
This study shows that moderate-term dimethyl fumarate treatment reduces dystrophic muscle pathology in a mouse model of Duchenne muscular dystrophy, with anti-inflammatory, anti-fibrotic, and anti-lipogenic effects.
2 citations - PathologyJournal of Visualized ExperimentsPeer-reviewed
Stiffness Measurement of Retinal Capillaries and Subendothelial Matrix using Atomic Force Microscopy
Irene Santiago Tierno, Mahesh Agarwal, Nikolaos Matisioudis…·Kaustabh Ghosh
The paper provides a protocol for measuring retinal capillary and subendothelial matrix stiffness in mice using atomic force microscopy.