Patrìcia A. D'Amore

Mechanism of PMC (2,2,5,7,8-pentamethyl-6-chromanol), a sterically hindered phenol antioxidant, in rescuing oxidized low-density lipoprotein-induced cytotoxicity in human retinal pigment epithelial cells

This study investigates how PMC, a sterically hindered phenol antioxidant, protects human RPE cells from ox-LDL-induced damage by inhibiting Nrf2-mediated antioxidant response.

Deletion of the endothelial glycocalyx component endomucin leads to impaired glomerular structure and function

This study shows that deleting endomucin in endothelial cells causes structural and functional issues in kidney glomeruli, including podocyte damage and albuminuria.

Endomucin regulates the endothelial cytoskeleton independent of VEGF

This study shows that endomucin regulates endothelial cytoskeleton dynamics in angiogenesis independently of VEGF signaling.

Endomucin knockout leads to delayed retinal vascular development and reduced ocular pathological neovascularization

This study shows that Endomucin deficiency delays retinal vascular development and reduces pathological neovascularization in mouse models.