Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PathologybioRxivDOI 10.3389/fcell.2021.715211
- PathologybioRxiv
Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse
F. Seehusen, J. J. Clark, P. Sharma…·A. Kipar
This study investigates SARS-CoV-2 variant neuroinvasion in K18-hACE2 mice, finding CNS spread in all variants except Omicron, with microglial activation and immune cell apoptosis observed.
DOI 10.3390/v14051020 - PathologybioRxivPreprint
ADAM17 inhibition prevents neutrophilia and lung injury in a mouse model of Covid-19
N. L. Lartey, S. Valle-Reyes, H. Vargas-Robles…·M. Schnoor
This study shows that ADAM17 inhibition reduces neutrophilia and lung injury in a mouse model of Covid-19 by decreasing inflammation and adhesion molecule expression.
DOI 10.1101/2021.04.10.439288 - PathologybioRxiv
Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis
K. A. Britson, J. P. Ling, K. E. Braunstein…·T. E. Lloyd
Depletion of T cells in a xenograft model of sporadic inclusion body myositis suppresses inflammation but not TDP-43 pathology or muscle degeneration.
DOI 10.1126/scitranslmed.abi9196 - PathologybioRxivPreprint
Vibrio cholerae may be transmitted to humans from bullfrog through food or water
y. yang, x. zhu, y. chen…·x. ai
This study identifies Vibrio cholerae in diseased bullfrogs and suggests it can transmit to humans via bullfrog food and aquaculture water, posing a health risk.
DOI 10.1101/2021.04.09.439145 - PathologybioRxivPreprint
APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex
A. Saito, Y. Kageyama, O. Pletnikova…·J. C. Troncoso
This study shows that the APOE ε4 allele causes earlier age-related decline in amyloid β clearance in the human cortex, supporting early intervention strategies for Alzheimer's disease.
- PathologybioRxiv
Unraveling the host-selective toxic interaction of cassiicolin with lipid membranes and its cytotoxicity
K. X. Ngo, N. B. Quoc, P. D. N. Nguyen…·T. Ando
This study investigates how cassiicolin toxins interact with plant lipid membranes, showing that their cytotoxicity depends on lipid composition and that specific rubber clones resist the toxins.
DOI 10.1094/phyto-09-21-0397-r - PathologybioRxiv
Development of a mini-replicon-based reverse-genetics system for rice stripe tenuivirus
M. Feng, L. Li, R. Cheng…·X. Tao
This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.
DOI 10.1128/jvi.00589-21 - PathologybioRxiv
Susceptibility of rosaceous fruits and apple cultivars to postharvest rot by Paecilomyces niveus
This study identifies rosaceous fruits and apple cultivars susceptible to Paecilomyces niveus infection and highlights its ability to produce patulin and form resistant spores.
DOI 10.1094/pdis-04-21-0855-re - PathologyKidney InternationalPeer-reviewed
Imaging Renal Ultrastructure using a Fast and Simple Optical Clearing and Swelling Protocol
David Unnersjoe-Jess, Linus Butt, Martin Hoehne…·Hans Blom
This paper introduces a fast and simple optical clearing and swelling protocol for 3D visualization of kidney ultrastructure using conventional confocal microscopy.
DOI 10.1016/j.kint.2020.10.039 - PathologybioRxiv
Barrier effects on the spatial distribution of Xylella fastidiosa in Alicante, Spain
M. Cendoya, A. Hubel, D. Conesa, A. Vicent
The paper evaluates how different barriers affect the spatial distribution of Xylella fastidiosa in Alicante, Spain, using Bayesian hierarchical models to assess non-stationarity in disease spread.
DOI 10.1094/phyto-05-21-0218-r - PathologybioRxiv
Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models
J. Bragazzi Cunha, J. S. Elenbaas, D. Maitra…·B. Omary
This study identifies acitretin as a potential treatment for congenital erythropoietic porphyria by mitigating uroporphyrin-induced bone defects in a zebrafish model.
DOI 10.1038/s41598-021-88668-9 - PathologybioRxiv
Chaphamaparvovirus Antigen and Nucleic Acids are not Detected in Kidney Tissues from Cats with Chronic Renal Disease or Immunosuppressive Diseases
A. O. Michel, T. Donovan, B. Roediger…·S. Monette
The study investigates the presence of MKPV and related viruses in feline kidney tissues but finds no evidence of their involvement in feline chronic kidney disease.
DOI 10.1177/03009858211045439 - PathologybioRxiv
SARS-CoV-2, a threat to marine mammals? A study from Italian seawaters
T. Audino, C. Grattarola, C. Centelleghe…·C. Casalone
This study assesses the susceptibility of marine mammals in Italian waters to SARS-CoV-2 by analyzing ACE-2 receptor expression and evaluating wastewater exposure risks.
DOI 10.3390/ani11061663 - PathologyBMC BiologyPeer-reviewed
Large-scale transcriptomics to dissect two years of the life of a fungal phytopathogen interacting with its host plant
E. J. Gay, J. L. Soyer, N. Lapalu…·M.-H. Balesdent
This paper uses large-scale transcriptomics to analyze the gene expression of Leptosphaeria maculans over two years of interaction with its host plant, identifying 9% of genes involved in infection stages and revealing their chromatin localization.
DOI 10.1186/s12915-021-00989-3 - PathologybioRxiv
Brain Iron Imaging Markers in the Presence of White Matter Hyperintensities
K. D. Murray, M. N. Uddin, G. Schifitto…·J. Zhong
The paper evaluates brain iron deposition and white matter hyperintensities in cerebral small vessel disease using simulations and clinical data, finding that the Expected Iron Coefficient (EIC) is more sensitive to iron changes than other markers.
- PathologybioRxiv
Contemporary clinical isolates of Staphylococcus aureus from pediatric osteomyelitis patients display unique characteristics in a mouse model of hematogenous osteomyelitis
P. Roper, K. Eichelberger, L. Cox…·D. Veis
This study uses pediatric S. aureus isolates to create musculoskeletal infections in mice, showing strain-specific differences in infection outcomes.
DOI 10.1128/iai.00180-21 - PathologybioRxiv
Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia
Y. Miura, M. Lam, J. E. Bourke, S. KANAZAWA
This paper develops a novel mouse model of induced-usual interstitial pneumonia (iUIP) that exhibits bimodal fibrosis, resembling the progression from nonspecific interstitial pneumonia to UIP seen in idiopathic pulmonary fibrosis.
DOI 10.26508/lsa.202101059 - PathologybioRxivPreprint
First isolation of virulent Tenacibaculum maritimum strains from diseased orbicular batfish (Platax orbicularis) farmed in Tahiti Island
P. Lopez, D. Saulnier, S. Swarup-Gaucher…·E. Duchaud
The study isolates virulent Tenacibaculum maritimum strains from diseased orbicular batfish in Tahiti, linking them to white-patch disease and identifying genetic diversity among isolates.
DOI 10.1101/2021.03.15.435441 - PathologybioRxiv
Detection of Chronic Wasting Disease prions in fetal tissues of free-ranging white-tailed deer
C. K. Mathiason, A. V. Nalls, E. E. McNulty…·M. G. Ruder
The paper detects prion seeds in fetal tissues of white-tailed deer, suggesting potential mother-to-offspring transmission of CWD before birth.
DOI 10.3390/v13122430