X. Tao

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis

This study identifies a covalent inhibitor EN25 that targets GCLM to inhibit glutathione synthesis in ARID1A-deficient cancer cells.

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential

This study shows DFMO rebalances polyamine ratios in SRS patient cells and extends lifespan in a Drosophila model, suggesting therapeutic potential for SRS.

Epidemiological evaluation and identification of the insect vector of soybean stay-green associated virus

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

An intergeneric recombinant geminivirus causes soybean stay-green disease

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

A CRISPR-Cas assisted shotgun mutagenesis method for evolutionary genome engineering

This paper introduces CARM, a CRISPR-Cas-based method for whole-genome mutagenesis, and demonstrates its application in evolving yeast strains for increased beta-carotene and S-adenosyl-L-methionine production.

Time Evolution of the Stroke Symptom-Herb Networks Based on TCM Prescriptions

This study constructs and analyzes Stroke Symptom-Herb Networks (SSHNs) from historical TCM prescriptions to reveal their dynamic structure and evolutionary trends over 1700 years.

Analysis of the Mechanosensor Channel Functionality of TACAN

The paper investigates TACAN's functionality as a mechanosensitive ion channel and finds it does not exhibit mechanosensitive activity, instead showing structural features related to fatty acid elongase.

NMNAT promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosis

Development of a mini-replicon-based reverse-genetics system for rice stripe tenuivirus

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating

The paper investigates how phosphatidylinositol lipids, particularly PI(4,5)P2, affect Kir2.2 channel gating by analyzing burst and inter-burst durations in planar lipid bilayers.

STING suppresses cancer pain via immune and neuronal modulation

This study shows STING agonists reduce cancer pain and bone destruction in mouse models by modulating neurons, immune cells, and osteoclasts.

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.

Rescue of Tomato spotted wilt tospovirus entirely from cDNA clones, establishment of the first reverse genetics system for a segmented (-)RNA plant virus

This paper establishes the first reverse genetics system for a segmented negative-strand RNA plant virus, enabling molecular genetic analysis of its life cycle and pathogenicity.