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This paper develops a preclinical protocol for testing novel RUTF formulations using a rat model, assessing bone quality and gut microbiome dynamics to improve malnutrition treatment.

This study identifies seven transcripts uniquely altered by physical activity reduction in mice, linked to bioenergetic adaptation, using transcriptional profiling of gastrocnemius muscle.

This study shows that early-life challenge in zebrafish larvae alters cortisol regulation and neuropeptide expression, enhancing stress reactivity after an initial suppression period.

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

This study examines how temperature and parasite infection affect metabolic changes in pumpkinseed sunfish across biological scales, finding distinct impacts on whole-organism and cellular metabolism.

This study shows that early exposure to a Western diet in female mice leads to severe retinal and neurovascular issues, including anophthalmia and cataracts, highlighting the need for early intervention.

The paper investigates how morning insulin delivery route affects afternoon hepatic glucose uptake, finding that direct hepatic insulin signaling, not indirect actions, drives the second meal phenomenon.

The paper identifies a bacterial sensing mechanism in neurons that activates intestinal mitochondrial surveillance to protect against infections.

This study investigates the role of caveolin-1 in aortic root aneurysm development in MFS mice by examining its effects on endothelial and smooth muscle function, showing that Cav1 ablation increases NO production and improves aortic wall structure.

This study shows that Ffar4 and ChemR23 signaling in cardiac myocytes protects against ischemic injury by reducing oxidative stress and cell death.

This study shows that lysosomal calcium signaling via NAADP and calcium-stimulated adenylyl cyclase 1 and 8 contributes to the acute α-adrenergic response in atrial myocytes.

This study computes sex-specific survival curves for 12 nonhuman primate species to characterize aging patterns and provides insights into lifespan and healthspan differences.

This study shows that overexpressing ChR2-EYFP in skeletal muscle causes contractile dysfunction, while ChR2-only mice show normal function, highlighting the need for alternative optogenetic models.

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

This study compares oxygen titration strategies after ROSC in asphyxiated lambs, finding that rapid-wean reduces cerebral overperfusion and mitochondrial dysfunction.

This study quantifies how longitudinal bending stiffness and midsole foam affect running economy, finding similar improvements from a carbon fiber plate or PEBA foam.

This study shows that human skeletal muscle retains epigenetic memory of high-intensity interval training (HIIT) through hypomethylation and increased gene expression even after detraining.

This study shows that Ultra-small Particle Size Nanobubbles Water improves antioxidant activity and physical performance in chronically fatigued rats.

This study shows that knocking out the GH gene in mice increases lifespan and alters metabolic fuel utilization, directly linking GH to aging mechanisms.

This study shows that Winnie mice with chronic colitis develop skeletal muscle wasting linked to intestinal inflammation, with reduced muscle mass and size but preserved grip strength.