Discover, rate, and discuss biology preprints.

The paper predicts how MT-CYB mutations affect electron transfer in cancer and finds they are depleted in germline but enriched in tumors.

This study shows that pygopods, limbless geckos, have undergone similar evolutionary adaptations to snakes, with exceptional morphological and dietary evolution despite limited species diversity.

This study identifies three leukaemia stem cell subtypes in paediatric AML and shows that combining CLEC12A and CD84 targets all subtypes while sparing healthy cells.

The paper introduces a semantic publishing workflow for taxonomic studies, applying it to describe four new species of dung beetles and update taxonomic data.

This study shows c-di-AMP binds to Mycobacterium smegmatis RadA at a non-catalytic site, reducing its DNA-stimulated ATPase activity.

This study uses SANS and molecular dynamics to show that Cel7A adopts distinct conformations when bound to cellulose compared to free solution, highlighting dynamic structural changes during catalysis.

This study shows that early hematopoietic fate decisions are not strongly influenced by bone marrow niche identity, as fate-shaping signals are redundantly provided across niches.

The paper develops an AI-guided workflow to identify natural pocket proteins for small-molecule sensing, achieving 43.8% binding response in tested pairs and demonstrating portable device performance with low serum LODs.

This study identifies task- and leg-specific motor modules in Drosophila that enable curve walking by reconfiguring leg kinematics for arcs and turns.

OmniRE-seq quantifies RNA editing across bulk and single-cell data, identifying disease-related patterns and therapeutic targets in multiple models.

The paper investigates genome erosion in deep-sea symbionts and finds evidence of genome expansion through horizontal gene transfer and mobile elements, suggesting functional innovation can reverse erosion and enable host-switching.

This study compares the effects of nitrogen fertilization and alfalfa intercropping on intermediate wheatgrass yield across different sites and stand ages, finding that intercropping maintains yield without synthetic nitrogen.

The study examines microdiversity in Limnospira platensis across time and space, showing resilience and niche partitioning through genetic changes and horizontal gene transfer.

Morphi is an AI framework that quantitatively profiles organoid phenotypes using label-free microscopy, enabling drug screening by capturing viability and mechanistic responses.

This study engineers Yarrowia lipolytica to produce fatty alcohols by disrupting lipid metabolism pathways and optimizing culture conditions, achieving titers up to 19.4 g/L.

The paper maps ORC1 binding sites across the human genome, linking replication licensing to chromatin states, 3D genome organization, and replication timing.

This study identifies core microbiota associated with postlarval survival in shrimp through a meta-analysis of 16S rRNA gene datasets.

The paper analyzes parasite genotypes in sympatric mosquito species to show divergent selection on Plasmodium falciparum mediated by different vectors.

This study shows that macrophage-derived Legumain protease regulates ECM dynamics and proteome processing to enable scarless regeneration.

The paper evaluates how averaging perturbation responses in gene perturbation benchmarks affects the ability to assess perturbation-strength variation, finding that current models fail to reliably recover perturbation identity.