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An AI-assisted C++17 port of VarDictJava gives byte-identical calls on five exome samples while running 3.7-4.8 times faster on one core and needing 8-17 times less memory.

This study shows that Bmal1 in colon epithelial cells promotes mucus production and is essential for sex-specific tissue regeneration after injury.

This study uses proximity labeling to compare the interactomes of pyroglutamate-modified and unmodified amyloid beta in AD and control hippocampus, identifying unique and shared protein interactions.

This paper introduces a low-cost rhizobox platform for spatially resolved soil metabolomics under realistic conditions, showing reliable plant growth and species-specific metabolite profiles.

This study shows that LanCL proteins are essential for muscle regeneration in aging mice, as their loss impairs regeneration and increases inflammation.

This study shows that engineered NKG2C+ NK-like T cells have better antitumor effects and lower cytokine release syndrome risk than conventional CAR-T and CAR-NK cells.

TorchRef provides a PyTorch framework for crystallographic refinement, offering GPU acceleration and modular design for developing new refinement protocols.

The paper develops a time-space resolved fluorescence spectroscopy technique to study light-harvesting dynamics in Chlamydomonas cells under state transitions.

The paper uses in vitro transcribed RNA from genomic DNA to benchmark RNA modification detection by Nanopore direct RNA sequencing models.

The paper identifies a transcriptional switch in KLF activators and repressors during postnatal neuronal maturation using CRISPRi and integrates chromatin and gene expression data.

This study establishes normative green autofluorescence (GAF) values in rhesus macaques across different retinal regions and links GAF to age, intraocular pressure, and retinal structure.

This study shows Syntaxin11 primes Orai1 for CRAC channel function, affecting T cell cytotoxicity and gene expression without impacting membrane trafficking.

This paper introduces a formal framework for deriving synteny blocks directly from sequence data to better capture genomic rearrangements without obscuring structural variation.

This study characterizes MYT1L-Related Neurodevelopmental Disorder using data from the Brain Gene Registry, identifying cognitive, behavioral, and clinical features in affected individuals.

This study identifies ARF-1 as a regulator of cargo sorting at FERARI-dependent endosomal recycling hubs through its cycling between active and inactive states.

The paper introduces TheCOS, a thermo-responsive system for creating 3D tumor models with controlled cell localization and interactions, demonstrating its use in studying NK cell cytotoxicity in solid tumor environments.

This study identifies molecular mechanisms coordinating cell polarity, septins, and NOX signaling in nematode-trapping fungi for trap formation.