Jordan Scott Orange

The paper introduces TheCOS, a thermo-responsive system for creating 3D tumor models with controlled cell localization and interactions, demonstrating its use in studying NK cell cytotoxicity in solid tumor environments.

This study shows that KMT2D promotes effector molecule release in NK cells by regulating H3K4me1 and RAB3D levels, affecting cytotoxicity and cytokine production.

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.