Discover, rate, and discuss biology papers.

The paper identifies specific Golgi-associated tethers and their roles in distinct membrane recycling pathways in yeast.

The paper investigates how alternative respiratory electron transport pathways affect aminoglycoside susceptibility in bacteria.

The paper shows that Bruce, an autophagy-regulated inhibitor, suppresses Dcp-1 activity and wing tissue growth in Drosophila, independent of apoptotic pathways.

The paper identifies a novel mycovirus in clinical isolates of Cryptococcus neoformans, showing its presence in six isolates from HIV-positive patients with meningitis.

The paper identifies lung cancer susceptibility copy number variants (CNVs) and shows their potential role in genomic instability through association analyses and functional validation.

The paper models introgression of a small genomic block with weakly selected loci into a population, showing survival depends on selection strength relative to recombination.

The paper optimizes a flow cytometry sorting-sequencing workflow to reduce contamination and bias in microbial community analysis.

The paper examines T-cell receptor sequence diversity and HLA alleles in Midwestern Amish participants to explore associations with Alzheimer's disease and cognitive status.

The paper identifies APPM, a micropeptide that modulates OGDHc activity and ATP production, showing therapeutic potential in heart failure.

qcGEM introduces a quantum-chemistry-aware graph-based molecular representation that improves performance and interpretability in molecule-related tasks.

This paper evaluates MDL-001, a broad-spectrum antiviral, showing potent in vitro and in vivo activity against influenza, RSV, SARS-CoV-2, and hepatitis B/C/D viruses, with improved efficacy compared to existing treatments.

This study shows HDAC1 and HDAC2 are essential for alveolar macrophage homeostasis by suppressing Bim expression and co-regulating differentiation with LSD1.

MetaDome now supports GRCh38 alongside GRCh37, adds coordinate lookup, and identifies 52,463 GRCh38 ClinVar missense variants of uncertain significance with uncontradicted pathogenic evidence at homologous Pfam-domain positions.

This study compares two [FeFe] hydrogenases, showing that TgHydA1 remains more stable under oxygen than CbHydA1 due to slower reactivation rates.

This study shows that ventrolateral orbitofrontal cortex activity is required for updating spatial memories when new information is present, as evidenced by behavioral and hippocampal ensemble impairments.

This study compares the defibrillation efficacy of different channelrhodopsins in human cardiac tissue using simulations, finding that ion selectivity affects arrhythmia termination mechanisms and success.

This study compares the genomic diversity and evolution of goatpox and sheeppox viruses using pangenome graphs, revealing structural variation at inverted terminal repeats as a key driver of diversity.

This paper identifies lysosomal genes involved in sponge biosilicification and suggests their co-option for biomineralization across species.

The paper generates isogenic iPSC lines with CAG repeats and HTT KO for Huntington's disease study, showing differentiation potential and altered gene expression in neurons and astrocytes.