Discover, rate, and discuss biology preprints.

This paper introduces AutoSPECTRA, a protocol for auditing generalizability of scientific foundation models across biological domains.

This study identifies VLC fatty acyl-ceramides as essential for endocytic invagination by interacting with endocytic machinery and ORPs.

The paper develops a red fluorescent sensor, chILI, for detecting cAMP in living cells through intensity and lifetime imaging, demonstrating its use in mouse brain neurons.

This study identifies RBM25 as a post-transcriptional regulator that selectively stabilizes XBP1s mRNA during ER stress, enhancing UPR signaling and cellular survival.

This paper uses simulations to show that developmental control conceals genetic variation from selection, acting as an energy-dependent phenotypic capacitor that can be beneficial if harmful mutations are reversed.

This study shows that platelet-derived signals cause distinct endothelial dysfunction in bicuspid aortic valve disease, leading to mitochondrial dysfunction and immune cell recruitment.

This paper introduces XAMPGen, an interpretable generative model for discovering novel antimicrobial peptides using fine-tuned protein language models and explainable AI techniques.

This paper develops a 2D U-NET model to segment and quantify atherosclerotic lesions in mouse aortic sections, achieving high accuracy and significantly reducing measurement time.

The paper models genotype-specific photosynthetic trait trajectories using functional data analysis to predict biomass, finding that early growth period traits most strongly influence final dry weight.

This paper introduces a model-agnostic decomposition method to analyze differences in mean response between groups, using game-theoretic attribution and optimal transport coupling.

LRCQ estimates phenome-wide heritability enrichment of genomic loci using GWAS summary statistics, identifying enriched regions and their functional annotations.

The paper describes a method for reversible olfactory deprivation in mice using custom-made nose plugs and validates its effectiveness in post-weaning animals.

This study presents the structure of the human TIP60-C HAT module bound to a nucleosome, revealing how it positions the catalytic center on the nucleosome surface and engages the linker DNA.

This paper introduces Perturbscape, a framework that uses perturbation-induced gene programs to identify disease-relevant genes and pathways, showing higher heritability informativeness than steady-state approaches.

The paper identifies CD200R1 as a marker for an immature NK-cell precursor in tonsils, distinguishing between oligopotent and more restricted developmental stages.

The paper develops a thermodynamic model linking transcriptome organization to growth state by analyzing RNA folding free energies across cell cycle and stress adaptation.

GeneFamHunter recovers gene-family members from genome assemblies, outperforming existing methods in identifying divergent and tandemly arrayed genes.

This study shows HOX13 factors regulate chromatin accessibility through homodimerization and SWI/SNF recruitment, influencing lineage-specific transcriptional programs in iPSCs.

This study determines cryo-EM structures of FcR bound to IgM and IgA, revealing its binding mechanism and evolutionary insights into pIg receptor recognition.

This paper introduces dreems, a graph neural network that efficiently estimates effective migration surfaces from genetic data, achieving lower error and faster computation than existing methods.