Marie Kmita

This study shows HOX13 factors regulate chromatin accessibility through homodimerization and SWI/SNF recruitment, influencing lineage-specific transcriptional programs in iPSCs.

This study shows that variations in enhancer-promoter interactions at the Pitx1 locus lead to pathogenic activation in variable cell proportions, defining phenotypic severity in Liebenberg syndrome.

The paper maps the interactome of ARF and ARL proteins using BioID, identifies new localizations, and reveals functional roles of ARL14 in activating PLD1 and cargo trafficking.

The paper shows that PRC2 inactivation has minimal effect on PRC1 occupancy in developing limbs, highlighting the critical role of PRC2-independent PRC1 in gene regulation during limb development.

This study identifies Phox2a as a marker for anterolateral system neurons in mice and humans, showing their role in nociceptive signal relay and conservation across species.

The paper analyzes PRC1 and PRC2 binding dynamics during limb development, finding that many PRC-bound promoters are occupied exclusively by PRC1, independent of PRC2.

The paper shows HOX13 factors modulate HOXA11 target repertoire through chromatin accessibility, revealing a mechanism for HOX binding specificity.