Discover, rate, and discuss biology preprints.

golgi automates nerve model generation and recruitment simulation from images, offering a scalable open-source platform with Python API and GPU acceleration.

This study identifies nHOTAIRM1's role in axonal mRNA localization by scaffolding ANXA11-dependent transport assemblies in human motor neurons.

The paper assesses subtype-specific neutralization resistance of RSV-A and RSV-B isolates to mAbs and vaccines, finding RSV-A more resistant and bivalent vaccines more effective.

This study shows that lateralized foraging in mice leads to asymmetric corticostriatal plasticity, with increased cortical connectivity to striatal projection neurons in the ipsiversive hemisphere.

This study introduces fMObB, a mass spectrometry method to measure free methionine oxidation in E. coli, revealing higher oxidation under stress and the role of methionine sulfoxide reductases.

This study shows that Oxalis stricta exhibits consistent plastic responses to dicamba drift, increasing flower production but with variable reproductive outcomes, without significant genetic variation for hormesis.

GARAGE generates realistic synthetic scRNA-seq data by addressing high-dimensional, small-sample and rare-cell challenges using graph attention and adversarial generation.

The paper shows that prior expectations shape neural activity by increasing firing thresholds in neurons tuned away from expected directions, improving behavioral reliability.

This study investigates the role of protein synthesis in excitatory and inhibitory long-term plasticity in mouse hippocampus, finding distinct translational mechanisms for each.

The paper uses shotgun metagenomic sequencing to compare bacterial communities in plaque, saliva, and tumor samples from OSCC patients and healthy controls, identifying distinct microbial profiles.

This study identifies senomorphic and senolytic agents that counteract UV-induced senescence in XP-derived melanocytes, reducing SASP gene expression and related pathway activation.

This study identifies SASP factors that drive tumorigenesis in breast and lung cancer cells using a microarray platform and validates their role in growth and survival.

This paper develops a machine learning framework to predict antibacterial synergy using multi-level bioactivity features and demonstrates its performance under rigorous cross-validation.

This paper compares hydrothermal and microwave-assisted synthesis of carbon quantum dots from bearberry extract, showing how synthesis method affects surface chemistry, photophysical properties, and biological activity.

This study visualizes G2L4 reverse transcriptase's role in DNA repair via microhomology-mediated end joining using high-speed atomic force microscopy.

LGTM couples a neural topic model with additive basis-function Gaussian processes, learning microbial co-abundance topics and how covariates relate to their trajectories in longitudinal gut microbiome data.

This study shows that the membrane environment modulates internal hydration and catalytic activity of LpCopA, with hydration levels affecting ATPase function.

This paper models microbial regulatory feedback in organic matter decomposition, finding copiotrophic traits drive positive priming effects.

SCiMS predicts host chromosomal sex from metagenomic data, outperforming existing tools at low host coverage and across species.

This study identifies the CrdRS two-component system as a key regulator of antibiotic-induced biofilm formation in H. pylori through bidirectional control of transporters PlpA and GlnP.