Discover, rate, and discuss biology preprints.

The paper examines axon survival in chronically demyelinated taiep rats and finds that small diameter axons can survive for months with increased glial support.

HYphlow streamlines phylogenetic selection analyses by integrating data preparation, foreground assignment, HyPhy execution, and result extraction into a single workflow, improving precision and reproducibility.

This study integrates genetic and morphological data to delimit species in the millipede genus Pseudopolydesmus, finding congruence between genitalic morphology and molecular phylogeny.

This study investigates coenzyme specificity in yeast GDH3, showing how mutations alter coenzyme preference and revealing structural and evolutionary mechanisms of coenzyme regulation.

This study investigates APP's role in the endomembrane system, showing its impact on FE65 localization, ATF4 levels, and autophagy regulation.

BioResearchBench evaluates AI models on 50 biology research tasks, revealing low success rates and highlighting challenges in data analysis, interpretation, and experimental design.

This study examines how nutrient enrichment and water scarcity interact to affect floral traits and pollinator visitation in grassland species, showing species-specific responses and shifts in pollination dynamics.

CardioShift resolves cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes by accounting for nested variance, revealing hidden subpopulations and condition-dependent phenotypes.

This study identifies ABCB1 silencing in SDHB-deficient cancers and shows that vincristine improves progression-free survival in SDHB-mutant PPGL patients.

This study shows that sub-anesthetic ketamine reduces dyskinesia and improves motor function in female preclinical models of Parkinson's disease and L-DOPA-induced dyskinesia.

The paper develops DNA-based molecular machines to measure nanoscale membrane elasticity, revealing softer intracellular compartments compared to cytoplasmic membranes.

This study shows APOE4 worsens Aβ oligomer-induced synaptotoxicity by promoting autophagic degradation of STIM1 and Gpx4, leading to mitochondrial dysfunction and synaptic loss.

This study uses volumetric ultrasound localization microscopy to identify two reproducible gradients of cerebrovascular structure and flow in mice, defining axes of vascular density/flow complexity and flow speed/acceleration.

The paper investigates how different decision-making strategies in mice affect cortical activity and identifies frontal cortex involvement in engaged strategies.

The paper investigates if structural mechanisms of protein pocket engagement can predict drug-drug interactions without clinical data, finding high precision in identifying known interactions.

The paper studies human performance in a Cumulative Allocation Game, finding that participants deviate from optimal strategies due to loss aversion, reducing their expected growth rate by 25%.

This study shows that prolonged low-dose inhalation of paraquat in mice causes male-specific dopaminergic neuron loss and motor deficits, linking it to Parkinson's disease.

This study shows OPCs do not die during development, adulthood, remyelination, inflammation, or aging, indicating homeostasis does not rely on programmed cell death.

The paper shows that a balanced excitatory/inhibitory neuronal network can generate gliders that interact and compute, with high capacity near balance and low capacity with strong inhibition.