Julia M. Edgar

The paper examines axon survival in chronically demyelinated taiep rats and finds that small diameter axons can survive for months with increased glial support.

The paper identifies the myelinic channel system as a pathway for microtubule-dependent organelle transport in oligodendrocytes, showing its role in maintaining axonal integrity through neuronal activity and motor proteins.

This study shows that mutant SOD1 aggregates in myelinic nanochannels and accelerates ALS progression in mice, highlighting the role of myelin channel integrity in disease.

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

The paper shows that neuronal cholesterol synthesis is critical for remyelination in chronic demyelination models and MS patients.