High prevalence of loss of Y chromosome in the spermatozoa of young cancer survivors
Jonatan Axelsson, Bożena Bruhn‐Olszewska, Daniil Sarkysian, Ellen Markljung, Monika Horbacz, Indira Plá, A Sanchez, Hannah A. Nenonen, Angel Elenkov, Jan Piotr Dumanski, Aleksander Giwercman
This study finds that cancer survivors have a higher prevalence of loss of Y chromosome in their spermatozoa compared to controls, suggesting it as a potential biomarker for genomic instability and disease risk.
medRxiv · Mar 23, 2026 · PreprintGenetic & Genomic Medicine