Indira Plá

Targeted Analysis of >1500 Plasma Proteoforms via Individual Ion Mass Spectrometry

This paper introduces two plasma proteoform panels, PPA 526 and PPA 1514, using Individual Ion Mass Spectrometry to quantify proteoforms in human plasma with high reproducibility and disease discrimination capability.

High prevalence of loss of Y chromosome in the spermatozoa of young cancer survivors

This study finds that cancer survivors have a higher prevalence of loss of Y chromosome in their spermatozoa compared to controls, suggesting it as a potential biomarker for genomic instability and disease risk.

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

Top-Down Proteomics Identifies Plasma Proteoform Signatures of Liver Cirrhosis Progression

This study uses top-down proteomics to identify plasma proteoform signatures that distinguish stages of liver cirrhosis progression.

Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts

The paper identifies six proteins that predict response to immune checkpoint therapy across three melanoma cohorts and correlate with patient survival.