Author

A. A. Apfelbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

E. R. Lawlor· 4 shared J. A. Jimenez· 2 shared S. N. Furlan· 2 shared A. A. Mujeeb· 1 shared A. Andjelkovic-Zochowska· 1 shared A. C. Latronico· 1 shared A. Calinescu· 1 shared A. Comba· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCancer Biology

E. R. Lawlor

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4 papers

Recent·Most cited

Carcinoma-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment

E. D. Wrenn, A. A. Apfelbaum, E. R. Rudzinski, X. Deng, W. Jiang, S. Sud, R. A. Van Noord, E. A. Newman, N. M. Garcia, V. J. Hoglund, S. S. Bhise, S. B. Kanaan, O. G. Waltner, S. N. Furlan, E. R. Lawlor

This study identifies a subpopulation of Ewing sarcoma cells with CAF-like properties that remodel the tumor microenvironment through ECM deposition.

bioRxiv · Apr 12, 2023 · PreprintCancer Biology

β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma

D. R. Mohan, K. S. Borges, I. Finco, C. R. LaPensee, J. Rege, A. L. Solon, D. W. Little, T. Else, M. Q. Almeida, D. Dang, J. Haggerty-Skeans, A. A. Apfelbaum, M. Vinco, A. Wakamatsu, B. M. P. Mariani, , G. D. Hammer

This study shows that β-catenin maintains adrenocortical carcinoma differentiation through chromatin and histone interactions, and that targeting EZH2 can disrupt this process and inhibit tumor growth.

bioRxiv · Jul 2, 2022 · PreprintCancer Biology

HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states

A. A. Apfelbaum, F. Wu, A. Hawkins, J. A. Jimenez, S. D. Taylor, E. R. Pfaltzgraff, J. Y. Song, C. Hall, D. M. Wellik, M. Ljungman, S. N. Furlan, R. J. H. Ryan, J. F. Sarthy, E. R. Lawlor

The paper identifies HOXD13 as a direct target of EWS-FLI1 and shows it modulates transcriptional states in Ewing sarcoma by antagonizing EWS-FLI1-dependent gene repression.

bioRxiv · Jan 31, 2022 · PreprintCancer Biology

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy

M. S. Alghamri, K. Banerjee, A. A. Mujeeb, A. Taher, R. Thalla, B. L. McClellan, M. L. Varela, S. M. Stamatovic, G. Martinez-Revollar, A. Andjelkovic-Zochowska, J. V. Gregory, P. Kadiyala, A. Calinescu, J. A. Jimenez, A. A. Apfelbaum, , M. G. Castro

This paper develops synthetic protein nanoparticles delivering a CXCR4 inhibitor to treat glioma by enhancing immunotherapy and reducing tumor progression.

bioRxiv · Aug 27, 2021 · PreprintCell Biology