Author

R. J. H. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

M. Ljungman· 2 shared M. Y. Chiang· 2 shared A. A. Apfelbaum· 1 shared A. C. Monovich· 1 shared A. G. Muntean· 1 shared A. Hawkins· 1 shared A. Melnick· 1 shared A. R. Aguilar· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

M. Ljungman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

A. Melnick, S. Liang, Y. Liu, Q. Wang, N. Dean, E. Choe, N. Kunnath, G. Bodanapu, C. Mullin, F. Akter, K. Lin, B. Magnuson, S. Kumar, D. B. Lombard, A. G. Muntean, , M. Y. Chiang

This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.

bioRxiv · Jan 22, 2023Cancer Biology

ETV6 Deficiency and Microsatellite Enhancers Drive Transcriptional Dysregulation in B-Lymphoblastic Leukemia

R. Kodgule, J. W. Goldman, A. C. Monovich, T. Saari, C. N. Hall, N. Rajesh, J. Gupta, A. R. Aguilar, N. A. Brown, M. Y. Chiang, M. P. Cieslik, R. J. H. Ryan

This study identifies GGAA microsatellite enhancers as drivers of transcriptional dysregulation in ETV6-deficient B-ALL, revealing a novel epigenetic mechanism and limitations of animal models.

bioRxiv · Sep 20, 2022Cancer Biology

HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states

A. A. Apfelbaum, F. Wu, A. Hawkins, J. A. Jimenez, S. D. Taylor, E. R. Pfaltzgraff, J. Y. Song, C. Hall, D. M. Wellik, M. Ljungman, S. N. Furlan, R. J. H. Ryan, J. F. Sarthy, E. R. Lawlor

The paper identifies HOXD13 as a direct target of EWS-FLI1 and shows it modulates transcriptional states in Ewing sarcoma by antagonizing EWS-FLI1-dependent gene repression.

bioRxiv · Jan 31, 2022 · PreprintCancer Biology