S. N. Furlan

Carcinoma-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment

This study identifies a subpopulation of Ewing sarcoma cells with CAF-like properties that remodel the tumor microenvironment through ECM deposition.

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states

The paper identifies HOXD13 as a direct target of EWS-FLI1 and shows it modulates transcriptional states in Ewing sarcoma by antagonizing EWS-FLI1-dependent gene repression.

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.

The paper uses SIVS and scRNA-seq to analyze T cell infiltration and residency in the GI tract during aGVHD, identifying genes associated with tissue invasiveness and TRM programming.

IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer

This study shows that adding IL2 to rapamycin increases the persistence of ex-vivo expanded regulatory T cells in non-human primates, doubling their numbers in peripheral blood.