Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia
M. Murtadha, M. Park, Y. Zhu, E. Caserta, A. A. Dona, M. Singer, H. Vahed, T. Tandoh, A. Gonzalez, K. Ly, J. Sanchez, A. Chowdhury, A. Pozhitkov, L. Ghoda, L. Li, , F. Pichiorri
This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.
bioRxiv · Feb 27, 2023 · PreprintCancer Biology