A. Chowdhury

Timp2 loss-of-function mutation and TIMP2 treatment in murine model of NSCLC: modulation of immunosuppression and oncogenic signaling

TIMP2 treatment compensates for TIMP2 mutation to reveal immunomodulatory and oncogene regulation that inhibits tumor growth and metastatic niche formation.

Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues

This study investigates how matrix stiffness and alignment affect the structure and contractility of engineered myocardial tissues made from iPSC-derived cardiomyocytes.

PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

This paper identifies PITAR, a long noncoding RNA that inactivates p53 by stabilizing TRIM28 mRNA, and shows its role in glioblastoma progression and resistance to chemotherapy.

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival

This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

Bacterial communities associated with the surfaces of the fresh fruits sold around Dhaka Medical College and Hospital and their anti-microbial profiles

This study examines bacterial contamination on fresh fruits sold near a hospital in Bangladesh and identifies antimicrobial resistance genes among isolated pathogens.

Ultrafast molecular dynamics observed within a dense protein condensate

The paper studies molecular dynamics in dense protein condensates, finding rapid sub-microsecond reconfiguration despite high viscosity.

Translating DNA origami Nanotechnology to Middle School, High School, and Undergraduate Laboratories

This paper develops a streamlined DNA origami protocol for educational labs, enabling students to fabricate and analyze nanostructures in a 2-hour course with low-cost materials.

Spatiotemporal solidification of α-synuclein inside the liquid droplets

This study investigates the spatiotemporal solidification of α-synuclein within liquid droplets, showing how solid-like cores form and propagate during droplet aging and fusion.

Examining Batch Effect in Histopathology as a Distributionally Robust Optimization Problem

This paper shows that using abstention in a patch-based classifier improves performance in histopathology tasks while reducing reliance on spurious features.

The anti-immune dengue subgenomic flaviviral RNA is found in vesicles in mosquito saliva and associated with increased infectivity

The paper identifies subgenomic flaviviral RNA (sfRNA) in dengue-infected mosquito saliva, showing it enhances virus infectivity by inhibiting innate immunity.

JNK pathway restricts DENV, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands

The paper identifies the JNK pathway's role in restricting dengue, Zika, and chikungunya virus infection in mosquito salivary glands by activating complement and apoptosis.

Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting

This study shows that daratumumab targets CD38+ NK cells to induce immune activation and anti-myeloma activity despite reducing total NK cell frequency.