Author

L. Ghoda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. Marcucci· 3 shared A. Chowdhury· 2 shared A. Krishnan· 2 shared B. Zhang· 2 shared E. Caserta· 2 shared F. Pichiorri· 2 shared A. A. Dona· 1 shared A. Dona· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

G. Marcucci

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Author profile →

3 papers

Recent·Most cited

State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia

D. E. Frankhouser, R. C. Rockne, L. Uechi, D. Zhao, S. Branciamore, D. O'Meally, J. Irizarry, L. Ghoda, H. Ali, J. Trent, S. Forman, Y.-H. Fu, Y.-H. Kuo, B. Zhang, G. Marcucci

The paper uses transcriptome-based state-transition models to predict CML disease progression and treatment response using time-sequential blood samples from mice.

bioRxiv · Oct 11, 2023Cancer Biology

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

M. Murtadha, M. Park, Y. Zhu, E. Caserta, A. A. Dona, M. Singer, H. Vahed, T. Tandoh, A. Gonzalez, K. Ly, J. Sanchez, A. Chowdhury, A. Pozhitkov, L. Ghoda, L. Li, , F. Pichiorri

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

bioRxiv · Feb 27, 2023 · PreprintCancer Biology

Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting

D. Viola, A. Dona, E. Caserta, E. Troadec, E. G. Gunes, F. Besi, T. McDonald, L. Ghoda, J. F. Sanchez, J. Khalife, M. Martella, C. Karanes, M. Htut, X. Wang, M. Rosenzweig, , F. Pichiorri

This study shows that daratumumab targets CD38+ NK cells to induce immune activation and anti-myeloma activity despite reducing total NK cell frequency.

bioRxiv · Nov 22, 2019Cancer Biology