J. Sanchez

Unveiling miR-451a and miR-142-3p as Prognostic Markers in NSCLC via sEV Liquid Biopsy

This study identifies miR-451a and miR-142-3p as prognostic markers in NSCLC using sEV liquid biopsy, showing their association with treatment response and survival.

How does the ion concentration affect the functions of kinesin BimC

This study investigates how ion concentration affects BimC's function by analyzing electrostatic interactions between BimC and microtubules using molecular dynamics simulations.

Role of Glycogen Metabolism in Clostridioides difficile Virulence

This study investigates glycogen metabolism's role in C. difficile virulence, finding that glycogen accumulation enhances spore resilience and disease relapse.

The Horizontal Ladder Test (HLT) protocol: A novel, optimized, and reliable means of assessing motor coordination in Sus scrofa domesticus

The paper introduces a novel horizontal ladder test (HLT) protocol for assessing motor coordination in pigs and validates its construct validity using voluntary alcohol consumption.

A mutant fitness compendium in Bifidobacteria reveals molecular determinants of colonization and host-microbe interactions

The paper creates a mutant fitness compendium for Bifidobacterium breve to identify molecular factors affecting colonization and host-microbe interactions.

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

Stratigraphic distribution of ammonoids and other macrofossils from the upper Albian-lower Cenomanian interval in Putumayo, Colombia, northern South America: new data for mid-Cretaceous basin correlation

The paper reports new mid-Cretaceous ammonoid and macrofossil data from the Putumayo Basin, Colombia, providing biostratigraphic insights for regional correlation.

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

Systems biology illuminates alternative metabolic niches in the human gut microbiome

This study identifies the metabolic niche of Eggerthella lenta in the human gut by combining experimental and computational approaches, revealing its use of acetate and arginine catabolism.

Characterization of the Pace-and-Drive Capacity of the Human Sinoatrial Node: a 3D in silico Study

This study uses a 3D in silico model of the human sinoatrial node to investigate how its structure and electrophysiological properties enable successful pacing and driving of the heart.

High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle

The paper captures high-resolution crystal structures of transient phytochrome intermediates to elucidate the structural changes during the Pr-to-Pfr photocycle.

AML ImmunoPET: 64Cu-DOTA-anti-CD33 PET-CT imaging of AML in Xenograft mouse model

This paper develops a 64Cu-DOTA-anti-CD33 PET-CT imaging method for detecting AML in xenograft mouse models with high sensitivity and specificity, showing spatial heterogeneity in disease distribution.