Author

A. A. Gil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Approach:genetic perturbation / CRISPR· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J. E. Toettcher· 3 shared C. Carrasco-Lopez· 2 shared J. L. Avalos· 2 shared A. G. Goglia· 1 shared A. Lukacs· 1 shared C. L. Simmerling· 1 shared C. R. Hall· 1 shared E. M. Zhao· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

J. E. Toettcher

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Author profile →

3 papers

Recent·Most cited

Light-responsive monobodies for dynamic control of customizable protein binding

C. Carrasco-Lopez, E. Zhao, A. A. Gil, N. Alam, J. E. Toettcher, J. L. Avalos

This paper introduces light-responsive monobodies (OptoMBs) that can reversibly control protein binding affinity, demonstrating their utility in purification and potential for light-switchable applications.

bioRxiv · Mar 8, 2020 · PreprintBiochemistry

Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix

J. N. Iuliano, J. Tolentino Collado, A. A. Gil, P. V. Ravindran, A. Lukacs, S. Shin, H. A. Woroniecka, K. Adamczyk, J. M. Aramini, U. R. Edupuganti, C. R. Hall, G. M. Greetham, I. V. Sazanovich, I. P. Clark, T. Daryaee, , P. J. Tonge

This study investigates the structural dynamics of the LOV2 domain in AsLOV2, showing that Q513 and N414 mediate J-helix unfolding linked to optogenetic function.

bioRxiv · Jan 29, 2020Biophysics

Optogenetic control of protein binding using light-switchable nanobodies

A. A. Gil, E. M. Zhao, M. Z. Wilson, A. G. Goglia, C. Carrasco-Lopez, J. L. Avalos, J. E. Toettcher

This paper develops opto-nanobodies (OptoNBs) that enable light-switchable binding to target proteins, showing applications in modulating signaling and protein purification.

bioRxiv · Aug 18, 2019Biochemistry