Author

A. A. Witney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. d. Visch· 1 shared C. Roumestand· 1 shared F. Kloprogge· 1 shared G. V. Mukamolova· 1 shared H. Jagatia· 1 shared H. O'Hare· 1 shared I. L. Bartek· 1 shared J. Ortiz Canseco· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. d. Visch

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Understanding emergence of antimycobacterial dose dependent resistance.

F. Kloprogge, J. Ortiz Canseco, L. Phee, Z. Sadouki, K. Kipper, A. A. Witney, N. Stoker, T. D. McHugh

This study investigates how concentration-dependent resistance emerges to isoniazid and rifampicin, showing that genotypic resistance only appears when antibiotic levels fall below MIC, and that isoniazid resistance involves concentration-dependent SNP accumulation.

bioRxiv · Sep 2, 2022 · PreprintPharmacology & Toxicology

Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the global transcriptional regulator Lsr2

K. Alqaseer, O. Turapov, P. Barthe, H. Jagatia, A. d. Visch, C. Roumestand, M. Wegrzyn, I. L. Bartek, M. I. Voskuil, H. O'Hare, A. A. Witney, M. Cohen-Gonsaud, S. J. Waddell, G. V. Mukamolova

This study shows that PknB phosphorylates Lsr2, affecting its DNA binding and M. tuberculosis growth under hypoxia.

bioRxiv · Mar 8, 2019Microbiology