Author

T. D. McHugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

F. Kloprogge· 2 shared A. A. Witney· 1 shared A. Maitra· 1 shared a. Mdolo· 1 shared A. Pinto· 1 shared A. Rachow· 1 shared A. Saleh· 1 shared A.-M. Cujba· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

F. Kloprogge

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The impact of physiological state and environmental stress on bacterial load estimation methodologies for Mycobacterium tuberculosis

A. Maitra, M. Wijk, H. Margaryan, P. Denti, T. D. McHugh, F. Kloprogge

This study evaluates how bacterial growth phase and drug exposure affect bacterial load estimation methods for Mycobacterium tuberculosis.

bioRxiv · May 10, 2024 · PreprintMicrobiology

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

M. Woodall, A.-M. Cujba, K. B. Worlock, K.-M. Case, T. Masonou, M. Yoshida, K. Polanski, N. Huang, R. G. Lindeboom, L. Mamanova, L. Bolt, L. Richardson, S. Ellis, M. Palor, T. Burgoyne, , C. M. Smith

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

bioRxiv · Jan 16, 2023 · PreprintCell Biology

Understanding emergence of antimycobacterial dose dependent resistance.

F. Kloprogge, J. Ortiz Canseco, L. Phee, Z. Sadouki, K. Kipper, A. A. Witney, N. Stoker, T. D. McHugh

This study investigates how concentration-dependent resistance emerges to isoniazid and rifampicin, showing that genotypic resistance only appears when antibiotic levels fall below MIC, and that isoniazid resistance involves concentration-dependent SNP accumulation.

bioRxiv · Sep 2, 2022 · PreprintPharmacology & Toxicology

Improving diagnosis and monitoring of treatment response in pulmonary tuberculosis using the molecular bacterial load assay (MBLA)

W. Sabiiti, K. Azam, D. Kuchaka, B. Mtafya, R. E. Bowness, K. Oravcova, E. Farmer, I. Honeyborne, D. Evangelopoulos, T. D. McHugh, H. Xiao, C. Khosa, A. Rachow, N. Heinrich, E. Kampira, , S. H. Gillespie

This study evaluates the Molecular Bacterial Load assay (MBLA) for diagnosing and monitoring tuberculosis treatment response, finding it provides reliable, contamination-resistant results faster than traditional methods.

bioRxiv · Feb 28, 2019 · PreprintMicrobiology