Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis.
A. Amor Lopez, M. S. Mazariegos, A. Capuano, P. Ximenez Embun, M. Hergueta-Redondo, J. Angel Recio, E. Munoz, F. Al Shahrour, J. Munoz, D. Megias, R. Doliana, P. Spessotto, H. Peinado
The paper shows that EMILIN-1 is proteolyzed and secreted in small EVs, reducing its tumor suppressive effects and promoting melanoma progression and metastasis.
bioRxiv · Jun 2, 2021 · PreprintCancer Biology