D. Megias

Laser Scanning Confocal printing, a new simple method for micro-device fabrication (LSCprint method).

The paper introduces a new method for micro-device fabrication using a laser scanning confocal microscope and photosensitive resins, enabling rapid, cost-effective, and accessible microfluidic device creation in standard laboratories.

PP2A-B55alpha,delta phosphatase counteracts Ki67-dependent chromosome individualization during mitosis

The paper identifies PP2A-B55alpha,delta phosphatase as counteracting Ki67-dependent chromosome individualization during mitosis in mice.

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10

This study identifies mitochondrial and metabolic reprogramming induced by SARS-CoV-2 accessory proteins in lung cells, revealing potential therapeutic targets.

Pharmacological inhibition of titan-like cells formation suggests that accumulation of endogenous free radicals that correlate with mitochondrial changes are required to induce this transition in Cryptococcus neoformans

This paper identifies compounds that inhibit titan-like cell formation in Cryptococcus neoformans, suggesting that endogenous ROS and mitochondrial changes are critical for this process.

Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis.

The paper shows that EMILIN-1 is proteolyzed and secreted in small EVs, reducing its tumor suppressive effects and promoting melanoma progression and metastasis.

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

Wnt-mediated interactions of tumor-initiating cells with a macrophage niche drive skin tumor formation

The paper identifies a macrophage-tumor-initiating cell niche regulated by Wnt signaling that drives skin tumor formation and maintenance.

Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135

This study shows that Cep135 loss causes microcephaly in mice through p53-independent mechanisms due to neural progenitor adaptation failure to centriole defects.

Dynamic interactions of lymphatic vessels at the hair follicle stem cell niche during hair regeneration

This study shows lymphatic vessels interact with hair follicle stem cells during regeneration, expanding in response to HF growth and influencing tissue drainage.