Mast cells impair melanoma cell homing and metastasis by inhibiting HMGA1 secretion.
A. Benito-Martin, M. Hergueta-Redondo, L. Nogues, E. Castellano-Sanz, E. Garvin, M. Cioffi, P. Sola-Castrillo, W. Buehring, M. P. Ximenez-Embun, J. Munoz, I. Matei, J. Villanueva, H. Peinado
This study shows mast cells inhibit melanoma metastasis by reducing HMGA1 secretion, with HMGA1 expression linked to poorer survival in human melanoma.
bioRxiv · May 31, 2022Cancer Biology