E. Munoz

Etrinabdione (VCE-004.8), a B55a activator, promotes angiogenesis and arteriogenesis in critical limb ischemia.

This study shows that Etrinabdione (VCE-004.8) activates B55 to promote angiogenesis and arteriogenesis in critical limb ischemia by enhancing HIF-1 and reducing fibrosis.

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer`s disease by improving synaptic function and proteostasis

This study shows that overexpressing the active form of XBP1 in neurons reduces amyloid deposits and improves synaptic function in Alzheimer's disease models.

Characterization of the immune resistance of SARS-CoV-2 Mu variant and the immunity induced by Mu infection

This study identifies mutations in the SARS-CoV-2 Mu variant responsible for its immune resistance and shows that Mu-infected convalescent sera are broadly antiviral.

Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis.

The paper shows that EMILIN-1 is proteolyzed and secreted in small EVs, reducing its tumor suppressive effects and promoting melanoma progression and metastasis.

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

The paper develops a CBD derivative with dual BACH1 inhibition and NRF2 activation, showing neuroprotection in Huntington's disease cell models.

Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in murine models of chemically- and obesity-induced liver injury

This study shows that Δ9-Tetrahydrocannabinolic Acid reduces liver fibrosis and inflammation in mouse models of NAFLD induced by CCl4 or high-fat diet.

Tetrahydrocannabinolic Acid A (THCA-A) Reduces Adiposity And Prevents Metabolic Disease Caused By Diet-Induced Obesity

This study shows that THCA-A reduces adiposity and prevents metabolic disease in diet-induced obesity by acting as a partial PPARγ agonist.