H. Peinado

NGFR regulates germinal center B-cell activation and negative selection

This study shows that NGFR regulates germinal center B-cell activation and negative selection by maintaining GC structure and function, affecting antibody production and immune tolerance.

Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis

This study identifies endoglin (ENG) as a biomarker and therapeutic target for MPNSTs, showing that targeting ENG with antibodies or combining it with MEK inhibitors reduces tumor growth and metastasis.

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

This study shows that circulating tumor extracellular vesicles can be used to monitor genomic and transcriptomic changes in metastatic prostate cancer through liquid biopsy.

Mast cells impair melanoma cell homing and metastasis by inhibiting HMGA1 secretion.

This study shows mast cells inhibit melanoma metastasis by reducing HMGA1 secretion, with HMGA1 expression linked to poorer survival in human melanoma.

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis.

This study characterizes plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastases, finding reduced EV numbers and increased PD-L1 in melanoma patients with brain metastases.

Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis.

The paper shows that EMILIN-1 is proteolyzed and secreted in small EVs, reducing its tumor suppressive effects and promoting melanoma progression and metastasis.

Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

Exosomes are key regulators of non-cell autonomous communication in senescence

This study identifies exosomes as key mediators of non-cell autonomous senescence by transmitting the senescent phenotype through a non-canonical interferon pathway.