Author

A. J. Holland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. E. Jewett· 3 shared G. M. LoMastro· 3 shared M. A. Strong· 2 shared A. Al Jord· 1 shared A. B. Goryachev· 1 shared A. Bisio· 1 shared A. Curinha· 1 shared A. Friskes· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCell Biology

C. E. Jewett

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Author profile →

6 papers

Recent·Most cited

Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome

A. Curinha, Z. Huang, T. Anglen, M. A. Strong, C. R. Gliech, C. E. Jewett, A. Friskes, A. J. Holland

This study shows that HYLS1 mutations cause centriole structural defects leading to ciliary dysfunction and developmental issues in mice, mirroring human Hydrolethalus Syndrome.

bioRxiv · Mar 6, 2024Cell Biology

Exact centriole counts are critical for B cell development but not function

M. A. Schapfl, G. M. LoMastro, V. Z. Braun, M. Hirai, M. S. Levine, E. Kiermaier, V. Labi, A. J. Holland, A. Villunger

The paper shows that precise centriole counts are essential for B cell development but not for immune function.

bioRxiv · Feb 14, 2024 · PreprintCell Biology

The cell cycle variant in multiciliated cells incorporates 2 centriole biogenesis cycles

A.-R. Boudjema, R. Balague, C. E. Jewett, J. Serizay, G. M. LoMastro, O. Mercy, A. Al Jord, M. Faucourt, A. Schaeffer, C. Nous, N. Delgehyr, A. J. Holland, N. Spassky, A. Meunier

This study shows the MCC cell cycle variant accelerates centriole biogenesis by overlapping two cycles to produce multiple mature centrioles without cell division.

bioRxiv · Feb 9, 2024 · PreprintCell Biology

The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores

M. Burigotto, V. Vigorito, A. Mattivi, C. Gliech, S. Ghetti, A. Bisio, G. Lolli, A. J. Holland, L. L. Fava

The paper shows that PLK1-dependent displacement of 53BP1 from kinetochores is essential for mitotic surveillance pathway activity.

bioRxiv · Mar 27, 2023Cell Biology

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

G. M. LoMastro, C. G. Drown, A. L. Maryniak, C. E. Jewett, M. A. Strong, A. J. Holland

This study shows PLK4 is essential for centriole amplification and apical surface area expansion in multiciliated cells, linking these processes in MCCs.

bioRxiv · Jun 6, 2022Cell Biology

Autoamplification and competition drive symmetry breaking: Initiation of centriole duplication by the PLK4-STIL network

M. Leda, A. J. Holland, A. B. Goryachev

The paper proposes a biophysical model explaining how the PLK4-STIL network initiates centriole duplication through autoamplification and competition, leading to symmetry breaking.

bioRxiv · Sep 29, 2018Cell Biology