A. Bidaud-Meynard

The clathrin adaptor AP-1B independently controls proliferation and differentiation in the mammalian intestine.

This study shows that AP-1B controls both proliferation and differentiation in the mouse intestine through distinct pathways involving polarity, YAP, and EGFR/mTOR.

V0-ATPase downregulation induces MVID-like brush border defects independently of apical trafficking in the mammalian intestine

This study shows that V0-ATPase depletion causes MVID-like microvillus atrophy in mouse intestinal organoids without affecting apical trafficking.

A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane

The paper identifies a V0-ATPase-dependent apical trafficking pathway essential for intestinal epithelial polarity and shows its depletion mimics Microvillus inclusion disease defects in C. elegans.

Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting

The paper shows that transcytosis helps maintain CFTR apical polarity by retrieving basolateral CFTR and counteracting missorting caused by mutations or loss of NHERF1 interaction.