Author

H. F. Farin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

F. R. Greten· 2 shared H. Clevers· 2 shared A. Bidaud-Meynard· 1 shared A. Bourdais· 1 shared A. Ernst· 1 shared A. Kirchmair· 1 shared A. Krogsdam· 1 shared A. Noureen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

F. R. Greten

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

H. Schuhwerk, C. Menche, I. Armstark, P. Gupta, K. Fuchs, R. van Roey, M. H. Mosa, C. I. Geppert, S. Baerthel, D. Saur, F. R. Greten, S. Brabletz, T. Brabletz, H. F. Farin, M. P. Stemmler

This study shows that ZEB1 in cancer-associated fibroblasts suppresses anti-tumor immunity and promotes metastasis, and its loss increases immune checkpoint sensitivity.

bioRxiv · Mar 28, 2023Cancer Biology

V0-ATPase downregulation induces MVID-like brush border defects independently of apical trafficking in the mammalian intestine

A. Bidaud-Meynard, O. Nicolle, A. Bourdais, M. Duclos, J. Saleh, F. Ruemmele, H. F. Farin, D. Delacour, D. Moshous, G. Michaux

This study shows that V0-ATPase depletion causes MVID-like microvillus atrophy in mouse intestinal organoids without affecting apical trafficking.

bioRxiv · Nov 4, 2022Cell Biology

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

C. Plattner, G. Lamberti, P. Blattmann, A. Kirchmair, D. Rieder, Z. Loncova, G. Sturm, S. Scheidl, M. E. Ijsselsteijn, G. Fotakis, A. Noureen, R. Lisandrelli, N. Boeck, N. Nemati, A. Krogsdam, , Z. Trajanoski

The paper uses patient-derived organoids and phosphoproteomics to study signaling crosstalk in colorectal cancer and identify off-target effects of kinase inhibitors.

bioRxiv · Sep 16, 2022Cancer Biology

Novel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids

S. Wiechmann, P. Maisonneuve, B. M. Grebbin, M. Hoffmeister, M. Kaulich, H. Clevers, K. Rajalingam, I. Kurinov, H. F. Farin, F. Sicheri, A. Ernst

The paper develops RBD variants that inhibit Ras effector binding, inducing senescence in non-tumorigenic cells and revealing Ras dependency in cancer organoids.

bioRxiv · Aug 28, 2019Cancer Biology