Author

A. Bueno-Orovio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Bioengineering· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:deep learning· 3 Assay:electrophysiology· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Rodriguez· 4 shared R. Doste· 2 shared A. Dasi· 1 shared A. Galione· 1 shared A. Garfinkel· 1 shared B. A. J. Lawson· 1 shared C. C. Drovandi· 1 shared C. N. Toepfer· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBioengineering

B. Rodriguez

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Towards prospective in-silico trials in atrial fibrillation: the case of polypharmacological SK and K2P channel block

A. Dasi, L. A. Berg, H. Martinez-Navarro, A. Bueno-Orovio, B. Rodriguez

The paper uses in-silico trials to evaluate the efficacy of SK and K2P channel block in atrial fibrillation, finding that combined block significantly improves cardioversion success.

bioRxiv · Mar 30, 2024 · PreprintBioengineering

Lysosomal calcium loading promotes arrhythmias by potentiating ryanodine receptor release

Z. Meng, R.-A. Capel, S. J. Bose, E. Bosch, S. d. Jong, R. Planque, A. Galione, R. A. Burton, A. Bueno-Orovio

This study shows lysosomal calcium handling promotes RyR spontaneous release by increasing SR-junction calcium gradient, and blocking lysosomal function reduces arrhythmias.

bioRxiv · Nov 9, 2022 · PreprintBiophysics

Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy

F. Margara, Y. Psaras, Z. J. Wang, M. Schmid, R. Doste, A. Garfinkel, G. G. Repetti, J. Seidman, C. Seidman, B. Rodriguez, C. N. Toepfer, A. Bueno-Orovio

The paper combines human iPSC-CMs and in-silico models to identify genotype-specific pathomechanisms and therapeutic targets in hypertrophic cardiomyopathy.

bioRxiv · Jun 8, 2022 · PreprintBioengineering

Remodelling of potassium currents underlies arrhythmic action potential prolongation under beta-adrenergic stimulation in hypertrophic cardiomyopathy

R. Doste, R. Coppini, A. Bueno-Orovio

This study identifies reduced potassium currents as the main mechanism of action potential prolongation in HCM under beta-adrenergic stimulation, leading to arrhythmogenic risks.

bioRxiv · Mar 1, 2022Physiology

ToR-ORd-dynCl: an update of the ToR-ORd model of human ventricular cardiomyocyte with dynamic intracellular chloride

J. Tomek, A. Bueno-Orovio, B. Rodriguez

The paper updates the ToR-ORd model of human ventricular cardiomyocytes to include dynamic intracellular chloride, improving long-term simulation stability without significant complexity increase.

bioRxiv · Jun 1, 2020 · PreprintPhysiology

Perlin Noise Generation of Physiologically Realistic Patterns of Fibrosis

D. Jakes, K. Burrage, C. C. Drovandi, P. Burrage, A. Bueno-Orovio, R. W. dos Santos, B. Rodriguez, B. A. J. Lawson

This paper introduces a computational method to generate physiologically realistic fibrosis patterns, demonstrating its application to cardiac fibrosis and showing micro-scale variability impacts on electrophysiology.

bioRxiv · Jun 19, 2019 · PreprintPhysiology