A. Galione

Alternative Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration

The paper identifies a splice variant-dependent localization of PMCA2 to lysosomes and links it to neurodegenerative diseases.

Lysosomal calcium loading promotes arrhythmias by potentiating ryanodine receptor release

This study shows lysosomal calcium handling promotes RyR spontaneous release by increasing SR-junction calcium gradient, and blocking lysosomal function reduces arrhythmias.

The efficiency of Grignard Pure™ to inactivate airborne SARS-CoV-2 surrogate

This study evaluates the effectiveness of Grignard Pure™ in reducing airborne MS2 bacteriophage concentration by 2-3 logs at specific concentrations over 60-90 minutes.

Release of acidic store calcium is required for effective priming of the NLRP3 inflammasome

This study shows that lysosomal Ca2+ release is essential for NLRP3 inflammasome priming and IL-1β production in mice with Niemann-Pick Type C or Tpcn1/Tpcn2 deficiency.

Acetylation of L-leucine switches its carrier from the L-amino acid transporter (LAT) to organic anion transporters (OAT)

This paper shows that N-acetyl-L-leucine is transported by organic anion transporters (OAT) instead of LAT, explaining its drug-like properties compared to L-leucine.

Glucose and NAADP trigger elementary intracellular β cell Ca2+ signals

This paper shows glucose and NAADP induce localized Ca2+ signals in beta-cells, revealing a new mechanism for glucose-stimulated insulin secretion.

Effects of N-Acetyl-Leucine and its enantiomers in Niemann-Pick disease type C cells

This study evaluates the effects of N-Acetyl-Leucine and its enantiomers on lysosomal volume in NPC cells, finding that N-Acetyl-L-Leucine is most effective.

Unexpected differences in the pharmacokinetics of N-acetyl DL-leucine enantiomers after oral dosing and their clinical relevance

This study investigates the pharmacokinetic differences between enantiomers of N-acetyl-leucine after oral dosing in mice, finding that the D-enantiomer accumulates and has different tissue distribution compared to the L-enantiomer.