Z. J. Wang

Understanding the emergence of the influenza A/H3N2 K subclade in its historical and evolutionary context

The paper investigates the emergence of the influenza A/H3N2 K subclade, finding limited antigenic change and age-dependent vaccine responses, suggesting non-antigenic selection pressures.

In Silico Evaluation of Cell Therapy in Acute versus Chronic Infarction: Role of Automaticity, Heterogeneity and Purkinje in Human

The paper uses human-based modeling to evaluate cell therapy in acute and chronic myocardial infarction, finding that cell heterogeneity and Purkinje system function influence arrhythmia risk.

Identifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles

The paper develops a deep-learning model to identify minimal tumour perturbations that enhance T-cell infiltration using spatial proteomic data from cancer samples.

Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy

The paper combines human iPSC-CMs and in-silico models to identify genotype-specific pathomechanisms and therapeutic targets in hypertrophic cardiomyopathy.

Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

This paper uses human ventricular electromechanical modelling to explain clinical phenotypes in acute and chronic myocardial infarction, showing that ionic remodelling impacts ECG changes and ejection fraction.

Allergen specific Treg upregulated by lung-stage schistosome infection alleviates allergic airway inflammation via inhibiting IgE secretion

This study shows that lung-stage schistosome infection reduces allergic airway inflammation by increasing allergen-specific Treg cells that inhibit IgE and Th2 cytokine production.

A novel reporter gene assay for pyrogen detection

This paper introduces a novel reporter gene assay for pyrogen detection using NF-κB activation in RAW 264.7 cells, showing sensitivity and applicability to various biological products.