S. Aparicio

Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

The paper analyzes copy number alterations in breast epithelial cells from BRCA mutation carriers and wildtype individuals, finding lineage-specific CNAs that mirror cancer genomes.

Single-cell DNA replication dynamics in genomically unstable cancers

The paper develops a method to infer DNA replication states from single-cell sequencing and analyzes replication dynamics in aneuploid cancers, finding correlations between replication timing and copy number changes.

A Multifunctional Anchor for Multimodal Expansion Microscopy

This paper introduces a multifunctional anchor for expansion microscopy, enabling simultaneous imaging of multiple biomolecules with reduced cost and complexity.

Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes

This study compares the toxicity of Mn3O4 nanoparticles and their precursor material across different in vitro models representing alveolar, oral, and dermal exposure routes.

The Imaging and Molecular Annotation of Xenografts and Tumours (IMAXT) High Throughput Data and Analysis Infrastructure

The paper presents an infrastructure for high-throughput data and analysis of tumour and xenograft samples using multimodal imaging and molecular annotation.

Evolutionary tracking of cancer haplotypes at single-cell resolution

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

The impact of mutational processes on structural genomic plasticity in cancer cells

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer

This study develops a quantitative fitness model to analyze clonal dynamics in cancer under genetic and pharmacologic perturbations, revealing how mutations and drug resistance shape tumor evolution.