Lymphangiogenesis driven by VEGF-C reshapes tumor immune landscape and enables tumor eradication by viral immunotherapy
Rubén Fernández‐Rodríguez, Sara Cuadrado‐Castano, A. Cole Edwards, Anita Rogic, Yonina Bykov, Ignacio Mena, Noelia Dasilva, Alice Oliffson Kamphorst, Rosa Karlić, Amir Horowitz, Adolfo García‐Sastre, Mihaela Skobe
This study shows that VEGF-C promotes lymphangiogenesis in tumors, enhancing immune cell infiltration and enabling complete tumor eradication with viral immunotherapy.
bioRxiv · Aug 27, 2025 · PreprintCancer Biology