Alice Oliffson Kamphorst

B cells sustain tumor-specific CD4 T cells to promote response to PD-1 targeted therapy

This study shows that B cells support tumor-specific CD4 T cells to enhance PD-1 blockade efficacy, but antibody secretion is not necessary for long-term survival.

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma

This study develops an immunocompetent mouse model of virus-induced liver fibrosis and hepatocellular carcinoma using Norway rat hepacivirus.

TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

Lymphangiogenesis driven by VEGF-C reshapes tumor immune landscape and enables tumor eradication by viral immunotherapy

This study shows that VEGF-C promotes lymphangiogenesis in tumors, enhancing immune cell infiltration and enabling complete tumor eradication with viral immunotherapy.

ICOS limits memory-like properties and function of exhausted PD-1+ CD8 T cells

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.