Rosa Karlić

Lymphangiogenesis driven by VEGF-C reshapes tumor immune landscape and enables tumor eradication by viral immunotherapy

This study shows that VEGF-C promotes lymphangiogenesis in tumors, enhancing immune cell infiltration and enabling complete tumor eradication with viral immunotherapy.

Learning the cellular origins of cancer using single-cell chromatin landscapes

This study uses single-cell chromatin accessibility data and machine learning to predict cancer cell origins, revealing new insights into tumor development and challenging existing views on cancer origins.

Somatic mutation landscape reveals differential variability of cell-of-origin for primary liver cancer

The paper uses whole-genome sequencing to predict cell-of-origin for primary liver cancers, finding heterogeneity in origin predictions across cancer types.

Tumor mutational landscape is a record of the pre-malignant state

The paper predicts cancer cell-of-origin from DNA sequences by matching mutational landscapes to chromatin modification patterns in normal tissues.