Author

A. Curiel-Garcia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. P. Olive· 3 shared A. Califano· 2 shared C. F. Palermo· 2 shared H. C. Maurer· 2 shared H. Hibshoosh· 2 shared L. Tomassoni· 2 shared S. A. Sastra· 2 shared A. Andren· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCancer Biology

K. P. Olive

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Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 19, 2023

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

A. Curiel-Garcia, S. Holmstrom, C. Castillo…·K. P. Olive

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

DOI 10.1101/2023.03.19.533333

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivMar 2, 2023

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

M. C. Hasselluhn, A. R. Decker-Farrell, L. Vlahos…·K. P. Olive

The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.

DOI 10.1158/2159-8290.cd-23-0240

humanmouse

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 29, 2022

ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells

B. Parejo-Alonso, A. Royo-Garcia, P. Espiau-Romera…·P. Sancho

This study shows that ALK signaling promotes tumorigenicity and chemoresistance in pancreatic cancer stem cells, and that ALK inhibitors can reduce CSC content and enhance chemotherapy effectiveness.

DOI 10.1101/2022.08.29.505637

humanexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivAug 14, 2017

Somatic genome editing with the RCAS/TVA-CRISPR/Cas9 system for precision tumor modeling

B. Oldrini, A. Curiel-Garcia, C. Marques…·M. Squatrito

This paper develops a mouse model using RCAS/TVA-CRISPR/Cas9 for in vivo somatic genome editing to generate accurate cancer models.

DOI 10.1038/s41467-018-03731-w

mousewhole-genome sequencing

𝕏 PostBluesky