Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
A. G. Raufi, I. Pellicciotta, C. Palermo, S. Sastra, A. Chen, E. Alouani, C. Maurer, M. May, A. Iuga, R. Rabadan, K. P. Olive, G. A. Manji
This study shows that combining gemcitabine with CXCR4 inhibitors and anti-PD1 therapy improves immune response and survival in pancreatic cancer models.
bioRxiv · Dec 24, 2023 · PreprintCancer Biology
A. Curiel-Garcia, S. Holmstrom, C. Castillo, C. F. Palermo, S. A. Sastra, A. Andren, L. Tomassoni, Z. Li, T. LeLarge, I. Sagalovskiy, D. R. Ross, W. Wong, K. Shaw, J. Genkinger, H. Hibshoosh, , K. P. Olive
This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.
bioRxiv · Mar 19, 2023 · PreprintCancer Biology
M. C. Hasselluhn, A. R. Decker-Farrell, L. Vlahos, D. H. Thomas, A. Curiel-Garcia, H. C. Maurer, U. N. Wasko, L. Tomassoni, S. A. Sastra, C. F. Palermo, T. C. Dalton, A. Ma, F. Li, E. J. Tolosa, H. Hibshoosh, , K. P. Olive
The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.
bioRxiv · Mar 2, 2023Cancer Biology
B. Parejo-Alonso, A. Royo-Garcia, P. Espiau-Romera, S. Courtois, A. Curiel-Garcia, S. Zagorac, I. Villaoslada, K. P. Olive, C. Heeschen, P. Sancho
This study shows that ALK signaling promotes tumorigenicity and chemoresistance in pancreatic cancer stem cells, and that ALK inhibitors can reduce CSC content and enhance chemotherapy effectiveness.
bioRxiv · Aug 29, 2022 · PreprintCancer Biology
V. B. Gubbala, N. Jyotsana, V. Q. Trinh, H. C. Maurer, R. F. Naeem, N. K. Lytle, Z. Ma, S. Zhao, W. Lin, H. Han, Y. Shi, T. Hunter, P. K. singh, K. P. Olive, M. C. B. Tan, , K. E. DelGiorno
The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.
bioRxiv · Oct 27, 2021Cancer Biology
P. Laise, M. Turunen, A. Curiel Garcia, L. Tomassoni, C. Maurer, E. Elyada, B. Schmierer, J. Worley, J. Kesner, X. Tan, E. Calvo Fernandez, K. Wong, U. Wasko, S. Tagore, A. L. E. Wang, , A. Califano
The paper identifies three developmental lineages in pancreatic cancer driven by master regulators and shows their association with MAPK activity and therapeutic vulnerabilities.
bioRxiv · Oct 27, 2020 · PreprintCancer Biology
D. M. Kremer, B. S. Nelson, L. Lin, E. Yarosz, C. J. Halbrook, S. A. Kerk, P. Sajjakulnukit, A. Myers, G. Thurston, S. Hou, E. S. Carpenter, A. Andren, Z. Nwosu, N. Cusmano, S. Wisner, , C. A. Lyssiotis
This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.
bioRxiv · Feb 28, 2020 · PreprintCancer Biology
K. E. DelGiorno, C.-Y. Chung, H. C. Maurer, S. Weiser Novak, R. R. Giraddi, D. Wang, R. F. Naeem, L. Fang, L. R. Andrade, N. K. Lytle, W. H. Ali, C. Tsui, V. B. Gubbala, M. Ridinger-Saison, M. Ohmoto, , G. Wahl
This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.
bioRxiv · Dec 19, 2019 · PreprintCancer Biology
M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive
The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.
bioRxiv · Nov 1, 2019 · PreprintCancer Biology
R. Singhal, K. P. Olive, C. A. Lyssiotis, Y. M. Shah
This study shows that HIF-2α overexpression makes colon cancer cells more sensitive to oxidative cell death, suggesting a potential therapeutic strategy.
bioRxiv · Oct 30, 2019 · PreprintCancer Biology
S. Venkat, A. A. Tisdale, J. R. Schwarz, A. A. Alahmari, H. C. Maurer, K. P. Olive, K. H. Eng, M. E. Feigin
This study identifies APA-driven gene expression changes in pancreatic ductal adenocarcinoma, revealing miRNA loss and therapeutic targets like CK1.
bioRxiv · Aug 30, 2019Cancer Biology