Author

A. Dakhovnik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:C. elegans· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Koeberle· 1 shared A. Martirosyan· 1 shared A. Nair· 1 shared A. Ori· 1 shared C. Statzer· 1 shared C. Y. Ewald· 1 shared E. Jongsma· 1 shared F. Wandrey· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPhysiology

A. Koeberle

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2 papers

Recent·Most cited

Youthful and age-related matreotypes predict drugs promoting longevity

C. Statzer, E. Jongsma, S. X. Liu, A. Dakhovnik, F. Wandrey, P. Mozharovskyi, F. Zuelli, C. Y. Ewald

The paper identifies drugs that promote longevity by screening for compounds that alter extracellular matrix gene expression and validate them using a collagen-based longevity surrogate marker in C. elegans.

bioRxiv · Jan 26, 2021Pharmacology & Toxicology

Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.

L. Espada, A. Dakhovnik, P. S. Chaudhari, A. Martirosyan, L. Miek, T. Poliezhaieva, Y. Schaub, A. Nair, N. Doering, N. Rahnis, O. Werz, A. Koeberle, J. Kirkpatrick, A. Ori, M. Ermolaeva

This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.

bioRxiv · Dec 3, 2019 · PreprintPhysiology