C. Y. Ewald

Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils

The paper investigates sex-dimorphic expression of ECM genes in mouse bone marrow neutrophils using bulk and single-cell transcriptomics.

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

This study shows that ADM-2, an orthologue of ADAM9, removes extracellular amyloid-beta aggregates in C. elegans, highlighting a role for metalloproteases in aggregate clearance.

Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in C. elegans

This study identifies rilmenidine as a caloric restriction mimetic that extends lifespan in C. elegans by activating the I1-imidazoline receptor and modulating pathways involved in stress resistance and autophagy.

Youthful and age-related matreotypes predict drugs promoting longevity

The paper identifies drugs that promote longevity by screening for compounds that alter extracellular matrix gene expression and validate them using a collagen-based longevity surrogate marker in C. elegans.

ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1

The paper shows that ATF-4 and hydrogen sulfide signaling mediate longevity from translation or mTORC1 inhibition in C. elegans.

Heterogeneity in heat shock response dynamics caused by translation fidelity decline and proteostasis collapse

This study quantifies heat-shock response heterogeneity in C. elegans and identifies translation fidelity and proteostasis collapse as drivers of individual lifespan differences.