A. de Visser

Density-dependent feedback limits the spread of a beta-lactamase mutant: experimental observations and population dynamic model

The paper investigates how cell density and antibiotic concentration affect the spread of beta-lactamase mutants, showing that density determines whether a resistant strain outcompetes or coexists with a susceptible strain.

Interaction between mutation type and gene pleiotropy drives parallel evolution in the laboratory

The paper investigates how mutation type and gene pleiotropy interact to influence evolutionary repeatability in Escherichia coli, finding that SNPs in highly pleiotropic genes provide greater fitness benefits than indels or structural variants.

Race to survival during antibiotic breakdown determines the minimal surviving population size

The paper develops a theoretical framework to quantify collective antibiotic resistance in bacterial populations, showing survival depends on the ratio of death and antibiotic removal rates and cooperativity.

The fitness landscape of TEM-1 β-lactamase is stratified and inverted by sublethal concentrations of cefotaxime

This study maps the fitness landscape of TEM-1 β-lactamase mutants under cefotaxime stress, showing stratified landscapes in unstructured environments and fitness advantages for susceptible genotypes in structured environments.

Stochastic effects during the establishment of β-lactam resistant E. colimutants indicate conditions for collective resistance

The paper quantifies single-cell establishment probabilities of β-lactam resistant E. coli mutants under different antibiotic concentrations and environments, revealing stochastic effects and cooperative resistance mechanisms.